Regioselectivity of the acidolysis of 2-(chloromethyl)oxirane with aromatic acids in the presence of organic bases

doi:10.1134/S107042801403004X

Paper

Regioselectivity of the acidolysis of 2-(chloromethyl)oxirane with aromatic acids in the presence of organic bases

Published Apr 23, 2014 · M. Sinel’nikova, E. Shved

Russian Journal of Organic Chemistry

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Abstract

Regioselectivity of the reaction of 2-(chloromethyl)oxirane with aromatic acids in the presence of tertiary amines and tetraalkylammonium halides has been studied. Opening of the oxirane ring follows simultaneously SN2 and borderline SN2 mechanisms. The regioselectivity of the acidolysis of substituted oxiranes is determined by acid-base properties of the reactants and catalysts and steric factor. The regioselectivity increases as the contribution of the SN2 mechanism increases.

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The regioselectivity of acidolysis of 2-(chloromethyl)oxirane with aromatic acids increases as the contribution of the SN2 mechanism increases, influenced by acid-base properties of reactants and catalysts, and steric factors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Regioselectivity of the acidolysis of 2-(chloromethyl)oxirane with aromatic acids in the presence of organic bases

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References

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