D. Abramowicz, C. Keese, S. Lockwood
1990
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5
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Abstract
The regiospecific conversion of biphenyl to 4,4’-dihydroxybiphenyl (biphenol) by various fungi has been studied for several years. These selective enzymatic hydroxylation syntheses of biphenols are of interest as model xenobiotics for the mammalian metabolism of aromatics (Smith and Rosazza 1974) and as screening systems for carcinogens utilizing 4,4′-dihydroxybiphenyl as the probe (McPherson et al. 1976). Our interest in these systems concerns the production of 4,4’-dihydroxybiphenyl as an intermediate in the plastics and dye industries (Schwartz 1979; Fewson 1981; Cain 1980). For example, the biphenol diol is a monomer in Union Carbide’s polymer Radel™ and GE’s engineering polymer Ultem II™. The organism Aspergillus parasiticus catalyzes the specific conversion of biphenyl to 4,4’-dihydroxybiphenyl in a one-step process.