Regulation of immune responses by L-arginine metabolism

doi:10.1038/nri1668

Paper

Regulation of immune responses by L-arginine metabolism

Published Aug 1, 2005 · V. Bronte, P. Zanovello

Nature Reviews Immunology

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1,694

Citations

99

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

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Study Snapshot

Increased L-arginine metabolism by myeloid cells can impair lymphocyte responses to antigen during immune responses and tumor growth.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Regulation of immune responses by L-arginine metabolism

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References

Citations

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Plasma arginine as a predictive biomarker for outcomes with immune checkpoint inhibition in metastatic colorectal cancer: a correlative analysis of the CCTG CO.26 trial

High baseline plasma arginine levels predict improved overall survival in patients with metastatic colorectal cancer treated with immune checkpoint inhibitors.

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Adjuvants, which redirect or amplify immune responses, are crucial for developing highly efficacious and durable vaccines against leishmaniasis, but their clinical trial success depends on factors like administration route and antigen type.