Reishi mushroom Ganoderma lucidum Modulates IgA production and alpha-defensin expression in the rat small intestine.

doi:10.1016/j.jep.2017.12.010

Paper

Reishi mushroom Ganoderma lucidum Modulates IgA production and alpha-defensin expression in the rat small intestine.

Published Mar 25, 2018 · Atsuhito Kubota, Masaki Kobayashi, Sota Sarashina

Journal of ethnopharmacology

Q1 SJR score

23

Citations

3

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Abstract

Abstract removed due to Elsevier request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Key takeawayReishi mushroom may reduce the risk of intestinal infection by inducing IgA secretion and increasing alpha-defensin-5 and RD-6 mRNA levels in the rat small intestine through a TLR4-dependent pathway.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Reishi mushroom Ganoderma lucidum Modulates IgA production and alpha-defensin expression in the rat small intestine.

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References

Submerged cultivation of Ganoderma lucidum and the effects of its polysaccharides on the production of human cytokines TNF-α, IL-12, IFN-γ, IL-2, IL-4, IL-10 and IL-17.

Ganoderma lucidum polysaccharides induce moderate to high levels of innate inflammation and modulate cytokine responses in activated lymphocytes, with extracellular polysaccharides showing a higher capacity to modulate IL-17 production.

Assembly and localization of Toll-like receptor signalling complexes

Understanding the molecular mechanisms of Toll-like receptor signaling can lead to the development of new drugs targeting pathological signaling in inflammatory and autoimmune diseases.

Newly described pattern recognition receptors team up against intracellular pathogens

Newly identified pattern recognition receptors complement existing ones, enhancing the effectiveness of innate immune responses against intracellular pathogens.

TLR-dependent T cell activation in autoimmunity

Autoimmune diseases can be induced by self-reactive T cells, which are activated by pathogen-associated molecular patterns (PAMPs) and Toll-like receptors, leading to pro-inflammatory cytokine production and T cell activation.

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

Paneth cells play a crucial role in maintaining intestinal homeostasis and defense against infection, with dysfunction leading to increased susceptibility to chronic inflammatory bowel disease.

Citations