X. H. Chan, Palang Chotsiri, Rebecca A. Capel
Oct 18, 2022
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Influential Citations
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Journal
British journal of clinical pharmacology
Abstract
Amodiaquine is a 4‐aminoquinoline used extensively for the treatment and prevention of malaria. Orally administered amodiaquine is largely converted to the active metabolite desethylamodiaquine. Amodiaquine can cause bradycardia, hypotension, and electrocardiograph QT interval prolongation, but the relationship of these changes to drug concentrations is not well characterized.