H. Fan
1990
Citations
0
Influential Citations
0
Citations
Journal
Yao xue xue bao = Acta pharmaceutica Sinica
Abstract
4,4-Bis(4-fluorophenyl) butanoic acid is an important pharmaceutical intermediate. It is usually prepared by Friedel-Crafts reaction of 4-(4-fluorophenyl) butyrolactone with fluorobenzene. But the ratio of products is often affected by reaction conditions. By applying sulfonation, the undesired isomer can be successfully removed.