Research Progress on the Pharmacological Action of Schisantherin A

doi:10.1155/2022/6420865

Paper

Research Progress on the Pharmacological Action of Schisantherin A

Published Feb 12, 2022 · Zehao Xiao, W. Xiao, Guilin Li

Evidence-based Complementary and Alternative Medicine : eCAM

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5

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Abstract

Schisantherin A (Sch A) is a dibenzocyclooctadiene lignan monomer isolated from the fruit of Schisandra chinensis (Turcz.) Baill. (S. chinensis). At present, many studies have shown that Sch A has a wide range of pharmacological effects, including its anti-Parkinson and anti-inflammatory effects and ability to protect the liver, protect against ischemia-reperfusion (I/R) injury, suppress osteoclast formation, and improve learning and memory. Its mechanism may be related to the antioxidant, anti-inflammatory, and antiapoptotic properties of Sch A through the MAPK, NF-κB, AKT/GSK3β, and PI3K/AKT pathways. This is the first review of the recent studies on the pharmacological mechanism of Sch A.

Literature Review

Rigorous Journal

Study Snapshot

Schisantherin A, found in Schisandra chinensis fruit, has a wide range of pharmacological effects, including anti-Parkinson and anti-inflammatory effects, liver protection, and improved learning and memory, through antioxidant, anti-inflammatory, and antiapoptotic properties.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Research Progress on the Pharmacological Action of Schisantherin A

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References

An integrated strategy using LC-MS/MS combined with in vivo microdialysis for the simultaneous determination of lignans of Schisandra chinensis (Turcz.) Baill. Fructus and endogenous neurotransmitters: application in pharmacokinetic and pharmacodynamic studies.

Schisandra chinensis Fructus (SCF) shows potential in improving learning and memory in Alzheimer's disease rats, with better absorption and slower elimination than normal rats.

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Schisandra chinensis fruit extracts and their active compounds are potent antioxidants, mitoprotectors, and anti-inflammatory agents, offering potential benefits against various disorders.

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Combined 5-HT2A antagonism and mGlu 2 activation may provide greater relief for Parkinson's disease patients with dyskinesia and psychotic symptoms than either approach alone.

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Bicyclol shows potential as a therapeutic candidate for various liver diseases due to its wide spectrum of pharmacological properties and safety.

Citations

Effects of plant natural products on metabolic-associated fatty liver disease and the underlying mechanisms: a narrative review with a focus on the modulation of the gut microbiota

Plant natural products show potential in preventing and treating metabolic-associated fatty liver disease by targeting gut microbiota, offering a safer and more effective alternative to current treatments.

Cardioprotective Potential of Berries of Schisandra chinensis Turcz. (Baill.), Their Components and Food Products

Schisandra chinensis berries and their components show cardioprotective properties due to their antioxidant and anti-inflammatory properties, mainly due to their lignan content.

Evaluation of the Effect of Phyto-Adaptogens on the Performance Capability of Outbred Female Mice

Eleutherococcus senticosus (50 mg/kg), Rhaponticum carthamoides (10 mg/kg) and Schisandra chinensis (25 mg/kg) exhibit the most pronounced actoprotective activity on outbred female mice in a forced swim test.