An Hong-wei
2010
Citations
0
Influential Citations
1
Citations
Journal
Journal of Hebei University of Science and Technology
Abstract
The asymmetric synthesis of S-and R-bisoprolol fumarate,a selective β1-blocker inhibitor with extensive clinical use,is presented in this paper.Firstly R-and S-epichlorohydrin is used as chiral reagent to directly react with 4-((2-isoproxyethoxy)methyl)-phenol,then further react with isopropylamine,finally react with fumarate to give the target product S-and R-bisoprolol fumarate with a total yield of 60.8% and an ee value is higher than 92%.