V. Waagen, Ingjerd Hollingsæter, V. Partali
Oct 1, 1993
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0
Influential Citations
27
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Journal
Tetrahedron-asymmetry
Abstract
Abstract The enzymatic hydrolysis of butanoic esters of 1-phenyl-, 1-phenylmethyl-, 1-[2-phenylethyl] and 1-[2-phenoxyethyl] ethers of 3-methoxy-1,2-propanediol has been studied by using lipases. Highest enantioselectivity E was obtained with Amano PS lipase for the phenyl ether E ≈ 55, and with lipase B from Candida antarctica for the other derivatives, E ≈ 20, > 100 and >55 respectively. The absolute configurations of the products were verified from comparison with reference compounds synthesised from ( S )-epichlorohydrin or ( S )-glycidol.