Resolution of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol (BMS 181100) and α-(3-chloropropyl)-4-fluorobenzenemethanol using lipase-catalyzed acetylation or hydrolysis

doi:10.1016/S0957-4166(00)86268-0

Paper

Resolution of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol (BMS 181100) and α-(3-chloropropyl)-4-fluorobenzenemethanol using lipase-catalyzed acetylation or hydrolysis

Published Oct 1, 1994 · R. Hanson, A. Banerjee, F. Comezoglu

Tetrahedron-asymmetry

UNKNOWN SJR score

9

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Study Snapshot

Lipase-catalyzed acetylation and hydrolysis can effectively resolve -(3-chloropropyl)-4-fluorobenzenemethanol and -(3-chloropropyl)-4-fluorobenzenemethanol, potentially yielding

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Resolution of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol (BMS 181100) and α-(3-chloropropyl)-4-fluorobenzenemethanol using lipase-catalyzed acetylation or hydrolysis

Sign up to use Study Snapshot

References

Lipase-catalyzed transesterification in organic solvents: Applications to the preparation of enantiomerically pure compounds

Lipase-catalyzed transesterification in organic solvents can effectively prepare enantiomerically pure compounds, especially from optically active substrates.

Microbial reduction of 1‐(4‐fluorophenyl)‐4‐[4‐(5‐fluoro‐2‐pyrimidinyl)‐1‐ piperazinyl]butan‐1‐one

Microbial strains can selectively reduce key intermediates in the synthesis of antipsychotic compound 6, offering potential for drug discovery.

Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.

Compound 16 shows potential as an atypical antipsychotic agent with low extrapyramidal side effects and potential for clinical evaluation in treating psychosis.

Effects of medium and of reaction conditions on the enantioselectivity of lipases in organic solvents and possible rationales

Organic solvents significantly influence the enantioselectivity of lipases in transesterification reactions, with temperature also affecting enzyme activity.

Potential antipsychotic BMY 14802 selectively binds to sigma sites

BMY 14802 shows potential as an antipsychotic agent with fewer side effects than current drugs, and selectively inhibits binding at the s site, offering a new approach for developing new antipsychotic agents.

Citations