Neoplastic response of F344 rats and B6C3F1 mice to the polymer and dyestuff intermediates 4,4'-methylenebis(N,N-dimethyl)-benzenamine, 4,4'-oxydianiline, and 4,4'-methylenedianiline.

doi:10.1093/JNCI/72.6.1457

Paper

Neoplastic response of F344 rats and B6C3F1 mice to the polymer and dyestuff intermediates 4,4'-methylenebis(N,N-dimethyl)-benzenamine, 4,4'-oxydianiline, and 4,4'-methylenedianiline.

Published Jun 1, 1984 · E. K. Weisburger, A. Murthy, Herman S. Liljaand

Journal of the National Cancer Institute

Q1 SJR score

43

Citations

2

Influential Citations

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Abstract

Feeding 4,4'-methylenebis(N,N-dimethyl)benzenamine [CAS: 101-61-1; 4,4'-methylenebis(N,N-dimethylaniline)] to inbred F344 rats increased the incidence of thyroid lesions (hyperplasia, adenomas, and carcinomas) in both sexes, especially in the female rats. 4,4'- Oxydianiline (CAS: 101-80-4) in the diet increased adenomas and carcinomas in the thyroid gland and neoplastic nodules and carcinomas in the liver of male and female F344 rats. In addition to increasing thyroid adenomas in females and hepatocellular adenomas or carcinomas in male and female B6C3F1 mice, 4,4'- oxydianiline increased adenomas of the harderian gland in male and female mice. 4,4'- Methylenedianiline (CAS: 101-77-9) in the drinking water increased neoplasms of the thyroid gland and liver in F344 rats and B6C3F1 mice.

Non-RCT

Animal Study

Study Snapshot

Feeding F344 rats and B6C3F1 mice with 4,4'-methylenebis(N,N-dimethyl)-benzenamine, 4,4'-oxydianiline, and 4,4'-methylenedianiline increases thyroid and liver neoplasms.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Neoplastic response of F344 rats and B6C3F1 mice to the polymer and dyestuff intermediates 4,4'-methylenebis(N,N-dimethyl)-benzenamine, 4,4'-oxydianiline, and 4,4'-methylenedianiline.

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References

Citations

Risk assessment—based verification of the CertiPURTM limit values for toluene diamine and methylene dianiline in flexible polyurethane foam

Sleeping on a mattress that satisfies the CertiPUR limit value does not pose undue risk to consumers due to low levels of aromatic diamine impurities.

Repeated-dose liver micronucleus test of 4,4'-methylenedianiline using young adult rats.

The repeated-dose liver micronucleus test effectively detects genotoxic effects in young adult rats, providing a cost-effective alternative to conventional tests.

Subchronic Thyroid Toxicity Evaluation of 4,4′-Methylenebis(N,N′-Dimethyl)Aniline in Fischer 344 Rats

MDA exposure in rats leads to increased thyroid weight and follicular cell hyperplasia, with a no-observed-adverse-effect level of 200 ppm.

Xenobiotic-induced liver injury and fibrosis

Xenobiotic-induced cholangiopathies are often underestimated and overlooked, but may progress to biliary fibrosis and cirrhosis, and may prime the liver for subsequent liver disease and contribute to hepatobiliary cancer development.

Characterization of biliary conjugates of 4,4'-methylenedianiline in male versus female rats.

Female rats show increased sensitivity to DAPM toxicity due to decreased conjugation of reactive metabolites, leading to greater levels of protein adduct formation.

Organic-solvent extraction of model biomaterials for use in the in vitro chromosome aberration test.

Organic-solvent extraction is more effective than medium extraction for evaluating the biological safety of biomaterials, as it can extract MDA and OTMG oligomers without needing S9 mix.