R. Dewall, K. Vasko, E. Stanley
Sep 1, 1971
Citations
0
Influential Citations
184
Citations
Quality indicators
Journal
American heart journal
Abstract
Abstract Allopurinol was found to have a profound effect on hemodynamic, ECG, and biochemical changes of experimental myocardial ischemia produced by coronary artery ligation in dogs and sheep. Following acute infarction, intravenously administered Allopurinol caused an increase of myocardial contractility and cardiac output, reversed or prevented electrocardiographic S-T changes of ischemic origin, and exhibited prolonged antiarrhythmic effects. It is suggested that prevention of the irreversible loss of purine base from the cell during hypoxic states is the biochemical action of this drug that results in rapid recovery of the stressed myocardium. The results of the experiments indicated that Allopurinol may be a useful agent for the treatment of coronary insufficiency.