Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

doi:10.1007/s40495-017-0106-1

Paper

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

Published Sep 14, 2017 · Yonghong Li, Victor Pham, Michelle Bui

Current Pharmacology Reports

Q2 SJR score

87

Citations

1

Influential Citations

Full textSemantic Scholar

Abstract

Purpose of ReviewRhodiola rosea extracts have been used as a dietary supplement in healthy populations, including athletes, to nonspecifically enhance the natural resistance of the body to both physical and behavior stresses for fighting fatigue and depression. We summarize the information with respect to the new pharmacological activities of Rhodiola rosea extracts and its underlying molecular mechanisms in this review article.Recent FindingsIn addition to its multiplex stress-protective activity, Rhodiola rosea extracts have recently demonstrated its anti-aging, anti-inflammation, immunostimulating, DNA repair, and anti-cancer effects in different model systems. Molecular mechanisms of Rhodiola rosea extracts’ action have been studied mainly along with one of its bioactive compounds, salidroside. Both Rhodiola rosea extracts and salidroside have contrast molecular mechanisms on cancer and normal physiological functions. For cancer, Rhodiola rosea extracts and salidroside inhibit the mTOR pathway and reduce angiogenesis through downregulation of the expression of HIF-1α/HIF-2α. For normal physiological functions, Rhodiola rosea extracts and salidroside activate the mTOR pathway, stimulate paracrine function, and promote neovascularization by inhibiting PHD3 and stabilizing HIF-1α proteins in skeletal muscles. In contrast to many natural compounds, salidroside is water-soluble and highly bioavailable via oral administration and concentrated in urine by kidney excretion.SummaryRhodiola rosea extracts and salidroside can impose cellular and systemic benefits similar to the effect of positive lifestyle interventions to normal physiological functions and for anti-cancer. The unique pharmacological properties of Rhodiola rosea extracts or salidroside deserve further investigation for cancer chemoprevention, in particular for human urinary bladder cancer.

Literature Review

Highly Cited

Study Snapshot

Rhodiola rosea extracts and salidroside show potential in anti-aging, anti-inflammation, immunostimulating, DNA repair, and cancer chemoprevention.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

Sign up to use Study Snapshot

References

Altered expression of TRAIL on mouse T cells via ERK phosphorylation by Rhodiola rosea L. and its marker compounds.

Rhodiola rosea L. extracts show potential in regulating TRAIL expression, potentially rescuing resistance to apoptosis in autoimmune diseases and cancer.

Foods and beverages and colorectal cancer risk: a systematic review and meta-analysis of cohort studies, an update of the evidence of the WCRF-AICR Continuous Update Project

High intake of red and processed meat and alcohol increases colorectal cancer risk, while milk and whole grains may have a protective role against the cancer, while the evidence for vegetables and fish is less convincing.

Disease Subtype–Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A

Withaferin A shows promising chemopreventative efficacy against at least two different subtypes of breast cancer, with mitotic arrest and apoptosis induction as common determinants.

Salidroside Attenuates Ventilation Induced Lung Injury via SIRT1-Dependent Inhibition of NLRP3 Inflammasome

Salidroside protects against ventilation-induced lung injury by inhibiting NLRP3 inflammasome activation through SIRT1-dependent inhibition.

Inhibition of PHD3 by salidroside promotes neovascularization through cell–cell communications mediated by muscle-secreted angiogenic factors

Salidroside, an active compound from Rhodiola, enhances blood perfusion recovery in hind-limb ischemia mice by promoting neovascularization through inhibition of PHD3 and estrogen receptor alpha.

Citations