A. Shadiack, SHUBH D. Sharma, D. Earle
Dec 1, 2006
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Journal
Drug Discovery Today: Therapeutic Strategies
Abstract
Sexual dysfunction affects millions of men and women worldwide. Preclinical and clinical studies demonstrate and confirm that melanocortin receptor agonists such as bremelanotide (PT141, a synthetic alpha-melanocyte stimulating hormone analog) improve male and female sexual function presumptively via action on receptors in the central nervous system, particularly within the hypothalamus. Bremelanotide initiates penile erections in males. A recent pilot study demonstrates that bremelanotide also increases sexual arousal and desire in females. Intranasally administered bremelanotide is well tolerated.