Ropivacaine: A review of its pharmacology and clinical use

doi:10.4103/0019-5049.79875

Paper

Ropivacaine: A review of its pharmacology and clinical use

Published Mar 1, 2011 · Gaurav Kuthiala, G. Chaudhary

Indian Journal of Anaesthesia

Q2 SJR score

391

Citations

15

Influential Citations

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Abstract

Ropivacaine is a long-acting amide local anaesthetic agent and first produced as a pure enantiomer. It produces effects similar to other local anaesthetics via reversible inhibition of sodium ion influx in nerve fibres. Ropivacaine is less lipophilic than bupivacaine and is less likely to penetrate large myelinated motor fibres, resulting in a relatively reduced motor blockade. Thus, ropivacaine has a greater degree of motor sensory differentiation, which could be useful when motor blockade is undesirable. The reduced lipophilicity is also associated with decreased potential for central nervous system toxicity and cardiotoxicity. The drug displays linear and dose proportional pharmacokinetics (up to 80 mg administered intravenously). It is metabolised extensively in the liver and excreted in urine. The present article details the clinical applications of ropivacaine and its current place as a local anaesthetic in the group.

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Study Snapshot

Ropivacaine is a long-acting local anaesthetic with reduced motor blockade and decreased potential for central nervous system toxicity and cardiotoxicity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Ropivacaine: A review of its pharmacology and clinical use

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References

Ropivacaine 0.1% with fentanyl 2 μg mL−1 by epidural infusion for labour analgesia

Epidural 0.1% ropivacaine with fentanyl 2 g mL1 at 10 mL h1 provides adequate analgesia in the first stage of labor, similar to 0.2% ropivacaine with fentanyl 2 g mL

Ropivacaine: a pharmacological review

Ropivacaine is a safer local anesthetic agent than bupivacaine, particularly effective for major peripheral nerve blocks and obstetrics, with potential for increased use in the future.

A Comparison of Intrathecal Plain Solutions Containing Ropivacaine 20 or 15 mg Versus Bupivacaine 10 mg

Ropivacaine 15 and 20 mg provide faster motor recovery and longer sensory block duration in spinal anesthesia for day surgery compared to bupivacaine 10 mg.

Comparison between bupivacaine 0.125% and ropivacaine 0.2% for epidural administration to outpatients with chronic low back pain

Both bupivacaine 0.125% and ropivacaine 0.2% are suitable for epidural administration to outpatients with chronic low back pain, providing effective analgesia and allowing active physiotherapy.

A prospective, randomized, double-blind comparison of epidural levobupivacaine 0.5% with epidural ropivacaine 0.75% for lower limb procedures

Levobupivacaine 0.5% 15 mL provides an epidural block with the same clinical profile as ropivacaine 0.75% 15 mL for adults undergoing lower limb surgery.

Comparison of the effects of intrathecal ropivacaine, levobupivacaine, and bupivacaine for Caesarean section.

The racemic mixture of bupivacaine combined with sufentanil remains an appropriate choice for Caesarean sections under spinal anesthesia, providing superior success rates and longer duration of analgesia and motor block.

Ropivacaine 0.1% with Sufentanil 1 &mgr;g/mL Inhibits In Vitro Growth of Pseudomonas Aeruginosa and Does Not Promote Multiplication of Staphylococcus Aureus

Ropivacaine 0.1% with sufentanil 1 &mgr;g/mL inhibits Pseudomonas aeruginosa growth and does not promote Staphylococcus aureus multiplication compared to saline.

Amide Local Anesthetics Potently Inhibit the Human Tandem Pore Domain Background K+ Channel TASK-2 (KCNK5)

Local anesthetics effectively inhibit background K+ channel function, potentially enhancing conduction blockade in various tissues.

Intrathecal Fentanyl Added to Hyperbaric Ropivacaine for Cesarean Delivery

Adding fentanyl 10 g to hyperbaric ropivacaine 18 mg for spinal anesthesia for cesarean delivery improves intraoperative anesthesia and increases analgesia in the early postoperative period without causing side effects.

Citations

Electrodiagnostic Assessment of Peri-Procedural Iatrogenic Peripheral Nerve Injuries and Rehabilitation.

Electrodiagnostic medical consultation and nerve imaging can accurately classify peri-procedural peripheral nerve injuries, guiding treatment, recovery, and rehabilitation.

Comparing the effect of ropivacaine peritonsillar injection before and after adenotonsillectomy on postoperative pain among pediatric patients: A double-blind randomized clinical trial.

Ropivacaine peritonsillar injection before adenotonsillectomy may be more beneficial than after surgery for postoperative pain management in children undergoing adenotonsillectomy.

Anesthetic Drugs: A Comprehensive Overview for Emergency Medicine

This paper provides a comprehensive overview of anesthetic drugs and key clinical pearls for ensuring patient safety in humans, serving as a convenient guide for residents and medical school trainees.

Local infiltration anesthesia with high dose ropivacaine and dexmedetomidine in major knee surgery is safe

High-dose ropivacaine and dexmedetomidine are safe for local infiltration anesthesia in major knee surgery, with no significant side effects or complications observed.

Enhancing the effectivity of topical anaesthesia – new approaches, formulations and agents with the possible application in dentistry

Topical anesthesia plays a crucial role in preventing and combating pain in dentistry, and new approaches, formulations, and agents show promise in increasing its effectiveness.