R. Walkup, P. D. Boatman, R. Kane
Aug 5, 1991
Citations
0
Influential Citations
20
Citations
Journal
Tetrahedron Letters
Abstract
Using a model system, a stereoselective assembly of the 1-oxaspirol[5.5]undec-4-ene-8-one ring system of the antileukemic natural products oscillatoxin D and 30-methyloscillatoxin D was demonstrated. A key step was an intramolecular attack of the C1-C3 β-ketoester enol on a silyl-activated 2,3-dihydro-4-pyranone to create a silyloxy analogue of the natural products' spirobicyclce ring system.