Paper
Strained ruthenium complexes are potent light-activated anticancer agents.
Published May 11, 2012 · B. Howerton, D. Heidary, E. Glazer
Journal of the American Chemical Society
Q1 SJR score
409
Citations
3
Influential Citations
Abstract
Strained ruthenium (Ru) complexes have been synthesized and characterized as novel agents for photodynamic therapy (PDT). The complexes are inert until triggered by visible light, which induces ligand loss and covalent modification of DNA. An increase in cytotoxicity of 2 orders of magnitude is observed with light activation in cancer cells, and the compounds display potencies superior to cisplatin against 3D tumor spheroids. The use of intramolecular strain may be applied as a general paradigm to develop light-activated ruthenium complexes for PDT applications.
Highly CitedStudy Snapshot
Strained ruthenium complexes show potent light-activated anticancer properties, with 2 orders of magnitude increased cytotoxicity in cancer cells and superior potencies to cisplatin against 3D tumor spheroids.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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