[Salts of 5-methylpyrazole-3-carboxylic acid with basically substituted adenine derivatives. Identification and lipolysis inhibitory activity (author's transl)].

Paper

[Salts of 5-methylpyrazole-3-carboxylic acid with basically substituted adenine derivatives. Identification and lipolysis inhibitory activity (author's transl)].

Published 1981 · K. Credner, M. Tauscher, L. Jozic

Arzneimittel-Forschung

UNKNOWN SJR score

1

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0

Influential Citations

Semantic Scholar

Abstract

5-Methylpyrazole-3-carboxylic acid forms salts with basically substituted adenine bases of type (4) or (5), which have significantly more lipolysis inhibitory activity than the free acid itself. The substance tested, 6-amino-9-[2-hydroxy-3-(N-methyl-N-2-hydroxyethyl)-aminopropyl]-purine-5-methyl pyrazole-3-carboxylate (16), causes a significant reduction of serum FFA levels in fasted rats, even at the very low dosage of 0.150 mg/kg b.w., whereas the free 5-methylpyrazole-3-carboxylic-acid shows significant activity in this model only at doses of 2 mg/kg b.w. and above. The salt also shows similar activity on serum triglycerides. The effect on FFA, triglyceride and cholesterol levels, respectively, in fasted rats lasts for at least 8 h.

Non-RCT

Animal Study

Study Snapshot

5-Methylpyrazole-3-carboxylic acid salts with substituted adenine bases show greater lipolysis inhibitory activity than the free acid, reducing serum FFA, triglyceride, and cholesterol levels in fasted rats for at least 8 hours.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

[Salts of 5-methylpyrazole-3-carboxylic acid with basically substituted adenine derivatives. Identification and lipolysis inhibitory activity (author's transl)].

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References

Citations

Molecular Identification of High and Low Affinity Receptors for Nicotinic Acid*

HM74A, a high affinity receptor for nicotinic acid, may facilitate the discovery of superior drug molecules to treat dyslipidemia.