Nadine V. Hanhan, Y. Tang, Ngon T. Tran
Apr 16, 2012
Citations
0
Influential Citations
57
Citations
Journal
Organic letters
Abstract
The scandium(III)-catalyzed enantioselective Hosomi-Sakurai allylation of isatins with various substituted allylic silanes is described. A catalyst loading as low as 0.05 mol % is utilized at room temperature to afford the 3-allyl-3-hydroxy-2-oxindoles in excellent yields and enantioselectivity up to 99% ee, including a demonstration of a gram-scale reaction. The effects of additives and varying silyl groups were explored to demonstrate the scope and application.