Idiopathic scoliosis: genetic and environmental aspects.

doi:10.1136/jmg.4.4.251

Paper

Idiopathic scoliosis: genetic and environmental aspects.

Published Dec 1, 1967 · F. V. D. George, Robert L. Fisher

Journal of Medical Genetics

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76

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1

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Abstract

Although numerous clinical studies of 'idiopathic' scoliosis have been reported (McCarroll and Costen, 1960; Riddle and Roaf, 1955; Stearns, Jo-Yun Tung Chen, McKinley, and Ponseti, 1955), the aetiology of this condition remains obscure. Such diverse explanations as abnormal vertebral growth, spinal muscle imbalance, postural alterations, and endocrine and metabolic disturbances have found adherents (American Orthopedic Association Research Committee, 1941). The many case reports of specific families having several affected members have implied that hereditary factors might be significant in this disorder (Garland, 1934; Molski, 1957; Sidler, 1938; Staub, 1922), and some investigators have even suggested simple modes of inheritance (Faber, 1936; WynneDavies, 1965). In spite of this previous work, there remains no convincing evidence that idiopathic scoliosis is predominantly influenced by either genetic or environmental factors. This study was undertaken to determine whether idiopathic scoliosis could be demonstrated to follow a predictable mode of inheritance, or to associate with maternal age or birth order.

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Study Snapshot

Idiopathic scoliosis is not a predictable mode of inheritance or associated with maternal age or birth order.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Idiopathic scoliosis: genetic and environmental aspects.

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References

The Biology of Mental Defect

Advances in medicine and genetics have significantly modified our views on mental subnormality, and this third edition is a welcome addition to the literature on the subject.

Treatment of scoliosis. Correction and internal fixation by spine instrumentation.

This new method of spine instrumentation using rods and hooks effectively corrects curves and stabilizes treated segments in a corrected position, with promising preliminary results.

Attempted Treatment of Scoliosis by Unilateral Vertebral Epiphyseal Arrest

Unilateral vertebral epiphyseal arrest failed to alter curve progression in scoliosis patients, suggesting a lack of organization and uniformity in cartilage-cell columns.

Birth order, parental ages, and sex of off-spring.

Birth order and paternal age significantly influence the sex of offspring, but mother's age has a small 1% effect.

Environmental Influences Related to the Aetiology of Congenital Dislocation of the Hip

Modern genetics has advanced to the point where environmental factors play a significant role in the etiology of congenital hip dislocation.

Metabolic studies of children with idiopathic scoliosis.

Children with idiopathic scoliosis have a serious disturbance in protein catabolism, leading to excessive nitrogen waste and sulphur-containing amino acid excretion.

Citations

Are the Spinal Changes in the Course of Scoliogeny Primary but Secondary?

The spinal growth changes in idiopathic scoliosis development are secondary, not primary-intrinsic, due to asymmetrical loads from muscular loads, growth, and gravity.

Outcome of Conservative Therapy of Adolescent Idiopathic Scoliosis (AIS) with Chêneau-Brace

The C-brace can help prevent scoliotic curve progression in adolescents with adolescent idiopathic scoliosis, but factors like curve topography and skeletal maturity influence the therapy effect.

Prevalence of idiopathic scoliosis in girls with central precocious puberty: effect of a gonadotropin-releasing hormone agonist

Girls with central precocious puberty have a higher prevalence of adolescent idiopathic scoliosis, and GnRH agonist treatment may suppress scoliosis progression in these patients.

Etiological Theories of Adolescent Idiopathic Scoliosis: Past and Present

Adolescent idiopathic scoliosis likely has multiple causes, with biomechanical, neuromuscular, genetic, and environmental factors playing a role in its development.

Physical Activities and Lifestyle Factors Related to Adolescent Idiopathic Scoliosis

Classical ballet training, a family history of scoliosis, and low BMI may be associated with adolescent idiopathic scoliosis, while lifestyle-related factors show no significant association.

Lateral Semicircular Canal Asymmetry in Idiopathic Scoliosis: An Early Link between Biomechanical, Hormonal and Neurosensory Theories?

Adolescents with idiopathic scoliosis exhibit morphological vestibular asymmetry, likely determined before birth, which may contribute to later morphological, hormonal, and neurosensory anomalies.