Feb 2, 2020
Citations
0
Influential Citations
0
Citations
Journal
Definitions
Abstract
A quinolone derivative with potential antineoplastic activity. Semaxanib reversibly inhibits AT P binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. T his agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells. Qeios · Definition, February 2, 2020