Sensitizing DNA Towards Low-Energy Electrons with 2-Fluoroadenine.

doi:10.1002/anie.201603464

Paper

Sensitizing DNA Towards Low-Energy Electrons with 2-Fluoroadenine.

Published Aug 22, 2016 · J. Rackwitz, J. Kopyra, I. Dąbkowska

Angewandte Chemie

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46

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2

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Abstract

2-Fluoroadenine ((2F) A) is a therapeutic agent, which is suggested for application in cancer radiotherapy. The molecular mechanism of DNA radiation damage can be ascribed to a significant extent to the action of low-energy (<20 eV) electrons (LEEs), which damage DNA by dissociative electron attachment. LEE induced reactions in (2F) A are characterized both isolated in the gas phase and in the condensed phase when it is incorporated into DNA. Information about negative ion resonances and anion-mediated fragmentation reactions is combined with an absolute quantification of DNA strand breaks in (2F) A-containing oligonucleotides upon irradiation with LEEs. The incorporation of (2F) A into DNA results in an enhanced strand breakage. The strand-break cross sections are clearly energy dependent, whereas the strand-break enhancements by (2F) A at 5.5, 10, and 15 eV are very similar. Thus, (2F) A can be considered an effective radiosensitizer operative at a wide range of electron energies.

Study Snapshot

2-Fluoroadenine ((2F) A) effectively enhances DNA strand breakage by incorporating into DNA, making it an effective radiosensitizer for cancer radiotherapy at a wide range of electron energies.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Sensitizing DNA Towards Low-Energy Electrons with 2-Fluoroadenine.

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References

Citations

Unraveling the Complexity of DNA Radiation Damage Using DNA Nanotechnology

DNA origami nanostructures can effectively quantify DNA damage caused by ionizing radiation, potentially enhancing cancer treatments and radiosensitizing therapeutics.

Surprising Radiolytic Stability of 8-Thiomethyladenine in an Aqueous Solution

8-Thiomethyladenine (ASCH3) shows no radiolytic effects in an aqueous solution, suggesting proton transfer in water plays a key role in determining radiosensitizing properties of modified nucleobases.

Molecular Processes for radiosensitizer compounds upon electron interactions

This study estimates electron-driven molecular processes for radiosensitizer molecules, aiding in cancer therapy treatment, using various correlations and methods.

Fragmentation of the DNA Lesion 8-oxo-Guanine by Low-Energy Electrons.

Electron-induced fragmentation of DNA lesion 8-oxo-guanine is distinct from native guanine, potentially producing complex reactions that could have detrimental or protective effects on the organism.

Lab-on-a-DNA origami: nanoengineered single-molecule platforms

Lab-on-a-DNA origami allows for precise placement of chemical entities, enabling single-molecule analysis and investigation of radiation-induced processes in DNA with unprecedented detail.