Serotonin involvement in the inhibition of luteinizing hormone (LH) release induced by prostaglandin D2 (PGD2) in castrated male rats.

doi:10.1016/0014-2999(88)90050-7

Paper

Serotonin involvement in the inhibition of luteinizing hormone (LH) release induced by prostaglandin D2 (PGD2) in castrated male rats.

Published Apr 27, 1988 · T. Koh, Y. Nakai, F. Kinoshita

European journal of pharmacology

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4

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Abstract

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Non-RCT

Animal Study

Study Snapshot

Prostaglandin D2 (PGD2) may involve a serotonergic mechanism in the suppression of luteinizing hormone (LH) secretion in castrated male rats.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Serotonin involvement in the inhibition of luteinizing hormone (LH) release induced by prostaglandin D2 (PGD2) in castrated male rats.

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References

Involvement of the serotonergic system in the prolongation of pentobarbital sleeping time produced by prostaglandin D2

Prostaglandin D2's depressant actions are linked to the serotonergic neurotransmitter system, as its ability to prolong pentobarbital sleeping time is diminished when serotonin levels are reduced.

Prostaglandin D2 in rat brain, spinal cord and pituitary: basal level and regional distribution.

Prostaglandin D2 is widely distributed in rat brain, spinal cord, and pituitary, with highest concentrations in pineal gland and neurointermediate pituitary, followed by anterior pituitary.

Suppressive effect of prostaglandin (PG)D2 on pulsatile luteinizing hormone release in conscious castrated rats.

PGD2 inhibits pulsatile luteinizing hormone secretion in castrated male rats, with opiate receptors playing a role in this inhibition.

Effects of a Synthetic Met5-enkephalin Analog on Plasma Luteinizing Hormone and Prolactin Levels in Conscious Orchiectomized Rats 1

FK33-824 inhibits luteinizing hormone secretion and stimulates prolactin release in conscious orchiectomized rats, with central dopaminergic mechanisms involved in this process.

Effects of prostaglandin D2 on membrane potential in neuroblastoma X glioma hybrid cells as determined with a cyanine dye.

Prostaglandin D2 depolarizes neuroblastoma X glioma cells, likely due to altered calcium permeability in the cell membrane.

Citations

Expression of messenger RNA for the prostaglandin D receptor in the leptomeninges of the mouse brain

Prostaglandin D receptor is highly expressed in the leptomeninges of the mouse brain, but not in the brain parenchyma.

Serotonin, a neurotransmitter involved in the regulation of luteinizing hormone release.

Serotonin plays a role in regulating luteinizing hormone secretion in female rats, with a weak permissive role in male rats and a stimulatory effect in ovariectomized rats when pretreated with E2.