Beita Zhao, Bing Xia, Xiaohan Li
Sep 5, 2020
Citations
2
Influential Citations
44
Citations
Quality indicators
Journal
Journal of agricultural and food chemistry
Abstract
Sesamol, a liposoluble lignan extraction, has already been proved to possess potent anti-inflammatory property and it could also regulate gut dysfunction. The purpose of the present research is to investigate the protective effect of sesamol on colitis mice. In the current research, sesamol treatment (100 mg/kg bodyweight/day) for 6 weeks inhibited the dextran sulphate sodium (DSS)-induced bodyweight loss of mice. Transmission electron microscopy (TEM) and H&E staining results showed that the DSS-induced histopathological changes of mice were also recovered by sesamol supplementation. In addition, DSS-induced inflammatory responses were inhibited by sesamol supplementation via NF-κB signaling pathway in mice colon. Moreover, sesamol treatment prevented gut barrier integrity damages by enhancing tight junction proteins expression (Occludin, Claudin-1, ZO-1) and recovering the loss of gut mucus layer. Furthermore, sesamol supplementation also increased the production of short-chain fatty acids (SCFAs) and changed the gut microbiome structure in colitis mice by enhancing the relative abundance of Coprococcuscus, Butyricicoccus, Odoribacter and AF12. In conclusion, sesamol could effectively ameliorate DSS-induced colitis by promoting gut microecology.