H. Lahlou, J. Guillermet, Marylis Hortala
Apr 1, 2004
Citations
5
Influential Citations
153
Citations
Quality indicators
Journal
Annals of the New York Academy of Sciences
Abstract
Abstract: Somatostatin is a neuropeptide family that is produced by neuroendocrine, inflammatory, and immune cells in response to different stimuli. Somatostatin acts as an endogenous inhibitory regulator of various cellular functions including secretions, motility, and proliferation. Its action is mediated by a family of G‐protein‐coupled receptors (called sst1‐sst5) that are widely distributed in the brain and periphery. The five receptors bind the natural peptides with high affinity, but only sst2, sst5, and sst3 bind the short synthetic analogs used to treat acromegaly and neuroendocrine tumors. This review covers the current knowledge in somatostatin receptor biology and signaling.