Sandrine M. Hell, Claudio F. Meyer, G. Laudadio
Dec 27, 2019
Citations
0
Influential Citations
52
Citations
Journal
Journal of the American Chemical Society
Abstract
Single electron reduction is more challenging for sulfamoyl chlorides than sulfonyl chlorides. However, sulfamoyl and sulfonyl chlorides can be easily activated by Cl-atom abstrac-tion by a silyl radical with similar rates. This later mode of acti-vation was therefore selected to access aliphatic sulfonamides applying a single-step hydrosulfamoylation using inexpensive olefins, tris(trimethylsilyl)silane and photocatalyst Eosin Y. This late-stage functionalization protocol generates molecules as complex as sulfonamide-containing cyclobutyl-spirooxindoles for direct use in medicinal chemistry.