Site-specific modulation of carcinogen-induced gastrointestinal tract nuclear anomalies in B6C3F1 mice by chloroform.

Paper

Site-specific modulation of carcinogen-induced gastrointestinal tract nuclear anomalies in B6C3F1 mice by chloroform.

Published Mar 1, 1991 · F. Daniel, T. Reddy, J. Stober

Anticancer research

Q2 SJR score

5

Citations

1

Influential Citations

Semantic Scholar

Abstract

Chloroform (CHCl3) is an established rodent carcinogen and a prevalent contaminant of chlorine-disinfected drinking water. Thus in the United States CHCl3, along with other trihalomethanes, is regulated not to exceed 100 ppb in potable water. Recently, several studies have shown that CHCl3 also has anti-cancer properties as it inhibits tumor growth in mouse liver and in the gastrointestinal tract of the rat. In this paper we show that CHCl3 also inhibits the propensity for three gastrointestinal tract carcinogens, benzo(a)pyrene (BAP), 1,2-dimethylhydrazine (DMH) and methylnitrosourea (MNU), to induce nuclear anomalies in the proximal colon of the B6C3F1 mouse. For example, in mice pre-adapted to 1800 ppm CHCl3 for 30 days prior to the carcinogen administration the level of nuclear anomalies induced in the proximal colon by BAP was reduced by four-fold (0.9 +/- 0.7 v. 3.6 +/- 1.0 anomalies/10 crypts; p less than 0.001) and two-fold for MNU (2.4 +/- 1.0 v. 4.6 +/- 1.6; p less than 0.001) and DMH (0.9 +/- 0.9 v. 1.7 +/- 0.8; p = 0.03). In the duodenum CHCl3 was effective at inhibiting unclear anomalies only for MNU (45.3 +/- 4.6 v. 30.4 +/- 3.5; p = 0.02). The inhibitory effect of CHCl3 does not extend to nuclear anomalies of the forestomach. The anti-cancer properties of CHCl3 are discussed in light of its cancer causing potential and possible application to human risk assessment.

Non-RCT

Animal Study

Study Snapshot

Chloroform has anti-cancer properties, inhibiting the propensity for three gastrointestinal tract carcinogens to induce nuclear anomalies in mice, with potential implications for human risk assessment.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Site-specific modulation of carcinogen-induced gastrointestinal tract nuclear anomalies in B6C3F1 mice by chloroform.

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References

Citations

Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case–Control Study in Spain and Italy

Long-term exposure to trihalomethanes in drinking water is not clear, but chloroform concentrations show a negative association with colorectal cancer.

Colorectal cancers and chlorinated water.

Oestrogen can reduce the risk of colorectal cancers by reducing the entrance and increasing the excretion of chemicals in chlorinated water.

VARIABILITY OF NEOPLASTIC PARAMETERS IN COLON TUMOURS, AND ITS SIGNIFICANCE IN DIAGNOSTIC PRACTICE

Combined analysis of multiple laboratory methods is essential for objective information on early colon cancerous changes and effective therapeutic predictions.