Smooth muscle relaxant properties and vasomotor actions of 2-amino-1-p-nitrophenylpropane-1,3-diol.

doi:10.1002/JPS.2600660908

Paper

Smooth muscle relaxant properties and vasomotor actions of 2-amino-1-p-nitrophenylpropane-1,3-diol.

Published Sep 1, 1977 · S. Banerjee, C. Mitra, A. Mukherjee

Journal of pharmaceutical sciences

Q2 SJR score

3

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0

Influential Citations

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Abstract

Experiments with the guinea pig ileum, trachea, and vas deferens, the rat fundal strip, the rabbit jejunum and aortic strip, and the toad heart indicated that 2-amino-1-p-nitrophenylpropane-1,3-diol, the hydrolytic product of chloramphenicol, inhibited smooth muscles. Its action was direct and not through any mediators. After intravenous administration, the compound produced vasodepression followed by an overshooting rise of blood pressure. Vasodepression was not mediated by adrenergic, cholinergic, or histaminergic mechanisms. Hypertension was a sympathomimetic effect. Muscle relaxant and cardiovascular effects of the compound were similar to those of chloramphenicol, although it had no antibacterial effect.

Non-RCT

Animal Study

Study Snapshot

2-amino-1-p-nitrophenylpropane-1,3-diol, the hydrolytic product of chloramphenicol, has smooth muscle relaxant and vasomotor effects similar to chloramphenicol, but no antibacterial effect.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Smooth muscle relaxant properties and vasomotor actions of 2-amino-1-p-nitrophenylpropane-1,3-diol.

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References

Muscle relaxant properties of chloramphenicol.

Chloramphenicol relaxes smooth muscles directly, potentially by interfering with the energy-generating mechanism, with varying degrees of relaxation depending on the concentration applied.

BIOCHEMICAL STUDIES ON CHLORAMPHENICOL (CHLOROMYCETIN) III. ISOLATION AND IDENTIFICATION OF METABOLIC PRODUCTS IN URINE

Chloramphenicol is mainly excreted in urine as a monoglucuronide derivative, with a significant portion of its nitro compounds being inactive degradation products.

Citations

Identification of the chloramphenicol-hydrolyzing enzyme of guinea pig liver as one of the nonspecific carboxylesterases.

Guinea pig liver has the highest chloramphenicol-hydrolyzing capacity among mammals, with the enzyme being related to acetanilide-hydrolyzing carboxylesterases in pig and rat livers.

Inhibition of rat liver mitochondrial monoamine oxidase by chloramphenicol and 2-amino-1-p-nitrophenylpropane-1,3-diol.

Chloramphenicol and its hydrolytic product, 2-amino-1-p-nitrophenylpropane-1,3-diol, have a strong inhibitory effect on rat liver mitochondrial monoamine oxidase, with reversible inhibition and noncompetitive behavior.