Sodium polyanethole sulfonate: a new macrophage-dependent polymyxin-inhibitable, polyclonal B cell activator.

doi:10.4049/jimmunol.121.3.823

Paper

Sodium polyanethole sulfonate: a new macrophage-dependent polymyxin-inhibitable, polyclonal B cell activator.

Published Sep 1, 1978 · C. I. Smith, L. Hammarström

Journal of immunology

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14

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0

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Abstract

The anionic detergent sodium polyanethole sulfonate was found to activate mouse B lymphocytes to increased cell division and formation of plaque-forming cells, possibly by an indirect mechanism. An increased cell division was also obtained in guinea pig and in rabbit lymphooid cell cultures. A strong similarity was found when comparing the dextran sulfate- and the sodium polyanethole sulfonate-sensitive cell population. Thus, the responding mouse cells resided in spleen and lymph node and also in fetal liver and bone marrow. The sensitive lymphocytes were dependent on the presence of macrophages or macrophage-replacing factors, since depletion of phagocytic cells resulted in loss of response. Addition of polymyxin B inhibited the stimulation, possibly through a direct interaction with the polyanion. In potency sodium polyanethole sulfonate was found to surpass dextran sulfate, making this benzene sulfonate a useful tool when studying lymphocyte responses.

In Vitro Study

Study Snapshot

Sodium polyanethole sulfonate is a potent macrophage-dependent, polymyxin-inhibitable, polyclonal B cell activator, with potential applications in studying lymphocyte responses.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Sodium polyanethole sulfonate: a new macrophage-dependent polymyxin-inhibitable, polyclonal B cell activator.

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References

Citations

The mosaic of autoimmunity. A classical case of inhalation of a polyclonal activating factor in a genetically and hormonally susceptible patient leading to multiple autoimmune diseases.

The mosaic of autoimmunity is characterized by diverse clinical presentations and complex genetic and hormonal factors, leading to a wide spectrum of autoimmune diseases.

Effects of lipopolysaccharide on macrophages analyzed with anti‐lipid A monoclonal antibodies and polymyxin B

Anti-lipid A monoclonal antibodies can selectively inhibit bacterial lipopolysaccharide-induced macrophage activation, suggesting the presence of four functionally distinct substructures on lipid A.

Technical aspects of the production and growth of hybridomas

Hybridoma production and growth can provide an unlimited source of homogeneous antibodies with specificity for one particular antigen, overcoming limitations in conventional antisera production.

Induction of human interleukin-1 production by polymyxin B.

Polymyxin B can stimulate human monocytes to produce and release interleukin-1, with a synergistic effect when combined with LPS, a known interleukin-1 inducer.

Polysaccharides with sulfate groups are human T-cell mitogens and murine polyclonal B-cell activators (PBAs). I. Fucoidan and heparin.

Fucoidan and heparin, both sulfated polysaccharides, are human T-cell mitogens and mouse polyclonal B-cell activators, but their responses are less intense.