A. Nefzi, M. Giulianotti, R. Houghten
May 28, 1998
Citations
0
Influential Citations
21
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones is described. Starting from a resin-bound protected cysteine, and employing reductive alkylation and amide formation, thiomorpholin-3-one derivatives have been synthesized through intramolecular thioether formatiom in good yield and high purity.