O. Pingkai
2007
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Antitumor peptide AP-9(YKLPGHHHHYRP) was synthesized by Fmoc-solid phase peptide synthesis,and the purity of the product was more than 98%.The coupling reaction between the difficult sequence Fmoc-Arg(Pbf)-OH and H-Pro-Trt resin was investigated.The results showed that the coupling reaction could be completed when it was carried out for 6min at 30℃ by microwave irradiation with THF-NMP(1∶1) as the solvent,and the yield could reach to 80.2%.