Paper
Solvent- and halide-free synthesis of pyridine-2-yl substituted ureas through facile C–H functionalization of pyridine N-oxides
Published Dec 5, 2016 · V. Rassadin, Dmitry P. Zimin, Gulnara Z. Raskil
Green Chemistry
Q1 SJR score
21
Citations
1
Influential Citations
Abstract
A novel solvent- and halide-free atom-economical synthesis of practically useful pyridine-2-yl substituted ureas utilizes easily accessible or commercially available pyridine N-oxides (PyO) and dialkylcyanamides. The observed C–H functionalization of PyO is suitable for the good-to-high yielding synthesis of a wide range of pyridine-2-yl substituted ureas featuring electron donating and electron withdrawing, sensitive, or even fugitive functional groups at any position of the pyridine ring (63–92%; 19 examples). In the cases of 3-substituted PyO, the C–H functionalization occurs regioselectively providing a route for facile generation of ureas bearing a 5-substituted pyridine-2-yl moiety.
Study Snapshot
This novel solvent- and halide-free synthesis of pyridine-2-yl substituted ureas using readily available pyridine N-oxides and dialkylcyanamides allows for the facile generation of useful ureas with electron donating, electron withdrawing, sensitive, or fugi
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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