Site-selective Sonogashira reactions of 1,2-dibromo-3,5-difluorobenzene

doi:10.1016/J.CATCOM.2012.03.022

Paper

Site-selective Sonogashira reactions of 1,2-dibromo-3,5-difluorobenzene

Published Aug 5, 2012 · S. Reimann, Peter Ehlers, M. Sharif

Catalysis Communications

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Abstract

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Study Snapshot

Sonogashira cross coupling reactions of 1,2-dibromo-3,5-difluorobenzene effectively produce various fluorinated benzene derivatives with high site-selectivity in favor of position 1.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Site-selective Sonogashira reactions of 1,2-dibromo-3,5-difluorobenzene

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References

Site‐Selective Synthesis of Arylated Indenones by Suzuki–Miyaura Cross‐Coupling Reactions of 2,3,5‐Tribromoinden‐1‐one

The Suzuki-Miyaura cross-coupling reaction of 2,3,5-tribromo-1H-inden-1-one with arylboronic acid allows for the selective synthesis of arylated indenones with different aryl groups.

Suzuki–Miyaura reactions of N -protected tribromopyrazoles. Efficient and site-selective synthesis of 3,4,5-triaryl-pyrazoles, 3,5-diaryl-4-bromopyrazoles and 5-aryl-3,4-dibromopyrazoles

Suzuki-Miyaura reactions of N-protected tribromopyrazoles efficiently synthesize various 3,4,5-triaryl-pyrazoles, 3,5-diaryl-4-bromopyrazoles, and 5-aryl-3,4-dibromopyrazoles, making

Synthesis and Photophysical Properties of Alkynylated Pyrimidines by Site‐Selective Sonogashira Reactions of 2,4,5,6‐Tetrachloropyrimidine; First Synthesis of Tetraalkynyl‐pyrimidines

This study successfully synthesized novel alkynyl-substituted pyrimidines with unique fluorescence properties using site-selective Sonogashira cross-coupling reactions of 2,4,5,6-tetrachloropyrimidine, enabling the synthesis of t

One-pot synthesis of fluorinated terphenyls by site-selective Suzuki–Miyaura reactions of 1,4-dibromo-2-fluorobenzene

This study demonstrates a one-pot synthesis of fluorinated terphenyls using 1,4-dibromo-2-fluorobenzene with arylboronic acids, resulting in fluorinated para-terphenyls with different terminal aryl groups.

Regioselective Palladium(0)‐Catalyzed Cross‐Coupling Reactions and Metal‐Halide Exchange Reactions of Tetrabromothiophene: Optimization, Scope and Limitations

The Suzuki reaction of tetrabromothiophene with arylboronic acids provides a regioselective approach to various compounds, with optimal conditions affecting yield and reaction efficiency.

Efficient Synthesis of Substituted Selenophenes Based on the First Palladium(0)-Catalyzed Cross-Coupling Reactions of Tetrabromoselenophene

Palladium(0)-catalyzed cross-coupling reactions of tetrabromoselenophene enable efficient synthesis of aryl-substituted selenophenes with high yields using a novel biaryl-monophosphine ligand.

Fluorine in medicinal chemistry.

Fluorinated compounds have a remarkable record in medicinal chemistry, providing lead compounds for therapeutic applications and highlighting the role and impact of fluorine substitution on drug potency.

Fluorine in Pharmaceuticals: Looking Beyond Intuition

Fluorine in pharmaceuticals can enhance bioavailability and modify drug properties, but its specific influence on docking interactions with proteins remains largely unexplored.

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