N. Jain, S. Kulkarni, D. Jain
Nov 1, 2012
Citations
0
Influential Citations
7
Citations
Quality indicators
Journal
Acta poloniae pharmaceutica
Abstract
Esomeprazole (ESO) is a proton pump inhibitor which is used as antiulcer agent. It is official in IP and USP. Chemically it is (Fig-1A) (S)-5methoxy-2-[(4-methoxy-3,5-dimethylpyridine-2yl) methylsulfinyl]-3H-benzimidazole (1-3). Several methods have been employed for the estimation of esomeprazole such as spectrophotometric method and RP-HPLC method (5-8). Naproxen (NAP); (Fig-1B) (S)-2-(6-methoxynapthalen-2-yl) propionic acid is used as non steroidal anti-inflammatory agent (1, 2, 4). Literature survey reveals that there are some UV and HPLC method for the estimation of naproxen in pharmaceutical formulations (9, 10). The review of literature revealed that no method was yet reported for the simultaneous estimation of both the drugs in combined dosage forms. This paper describes two simple, rapid, accurate, reproducible and economic methods for the simultaneous estimation of esomeprazole and naproxen in tablet formulations using simultaneous equation and absorbance ratio method.