Speed-dieting: dopamine agonists promote weight loss

doi:10.1038/s42255-019-0114-z

Paper

Speed-dieting: dopamine agonists promote weight loss

Published Aug 28, 2019 · Stephanie E. Simonds, M. Cowley

Nature Metabolism

Q1 SJR score

4

Citations

0

Influential Citations

Full text Semantic Scholar

Abstract

Dopamine is an important neurotransmitter with essential roles in movement control and salience, and implications in addiction as well as weight loss, decreased food intake and a reduced motivational drive to eat. Folgueira et al. now demonstrate that dopamine causes weight loss and increases brown adipose tissue temperature via activation of the dopamine receptor D2R in hypothalamic GABA-expressing neurons in mice, and treatment with the dopamine agonist cabergoline causes weight loss in humans.

Very Rigorous Journal

Study Snapshot

Key takeawayDopamine agonists, such as cabergoline, promote weight loss and increase brown adipose tissue temperature in mice and humans, suggesting their potential as a weight loss treatment.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Speed-dieting: dopamine agonists promote weight loss

Sign up to use Study Snapshot

References

Hypothalamic dopamine signalling regulates brown fat thermogenesis

Stimulation of dopamine receptors in the hypothalamus leads to weight loss and increased energy expenditure in rodents and patients treated with a dopamine receptor 2 agonist.

Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation

Zona incerta GABA neuron activation in mice leads to rapid binge-like eating and weight gain, with chronic stimulation causing persistent overeating and weight gain.

The suppression of appetite and food consumption by methylphenidate: the moderating effects of gender and weight status in healthy adults.

Methylphenidate reduces appetite and food consumption in healthy adults, except in obese males, suggesting gender differences in appetite suppression.

An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis.

Orexin neurons in the perifornical hypothalamus directly influence brown adipose tissue thermogenesis, potentially contributing to disrupted regulation of body temperature and energy metabolism in narcolepsy.

An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis

Orexin neurons in the perifornical hypothalamus directly influence brown adipose tissue thermogenesis, potentially contributing to disrupted regulation of body temperature and energy metabolism in narcolepsy.

Citations

Portuguese observational cross-sectional clinical imaging study protocol to investigate central dopaminergic mechanisms of successful weight loss through bariatric surgery

Successful weight loss through bariatric surgery may involve similar central dopamine receptor binding to normal-weight healthy individuals, with potential correlations to age, hormonal status, and neurobehavioral scores.

Silencing of dopamine receptor D5 inhibits the browning of 3T3-L1 adipocytes and ATP-consuming futile cycles in C2C12 muscle cells.

Silencing dopamine receptor D5 inhibits browning and ATP-consuming futile cycles in adipocytes, potentially offering insights into novel obesity treatments.