Speed-dieting: dopamine agonists promote weight loss

doi:10.1038/s42255-019-0114-z

Paper

Speed-dieting: dopamine agonists promote weight loss

Published Aug 28, 2019 · Stephanie E. Simonds, M. Cowley

Nature Metabolism

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4

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Abstract

Dopamine is an important neurotransmitter with essential roles in movement control and salience, and implications in addiction as well as weight loss, decreased food intake and a reduced motivational drive to eat. Folgueira et al. now demonstrate that dopamine causes weight loss and increases brown adipose tissue temperature via activation of the dopamine receptor D2R in hypothalamic GABA-expressing neurons in mice, and treatment with the dopamine agonist cabergoline causes weight loss in humans.

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Study Snapshot

Key takeawayDopamine agonists, such as cabergoline, promote weight loss and increase brown adipose tissue temperature in mice and humans, suggesting their potential as a weight loss treatment.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Speed-dieting: dopamine agonists promote weight loss

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References

Citations

Portuguese observational cross-sectional clinical imaging study protocol to investigate central dopaminergic mechanisms of successful weight loss through bariatric surgery

Successful weight loss through bariatric surgery may involve similar central dopamine receptor binding to normal-weight healthy individuals, with potential correlations to age, hormonal status, and neurobehavioral scores.

Silencing of dopamine receptor D5 inhibits the browning of 3T3-L1 adipocytes and ATP-consuming futile cycles in C2C12 muscle cells.

Silencing dopamine receptor D5 inhibits browning and ATP-consuming futile cycles in adipocytes, potentially offering insights into novel obesity treatments.