G. Ermut, N. Karalı, Nurten Özsoy
Jul 14, 2014
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Influential Citations
3
Citations
Quality indicators
Journal
Journal of Enzyme Inhibition and Medicinal Chemistry
Abstract
Abstract In this study, 5-chloro-3H-spiro-[1,3-benzothiazole-2,3′-indole]-2′(1′H)-one derivatives 3a–l were synthesized by the reaction of 1H-indole-2,3-diones 1a–l with 2-amino-4-chlorothiophenol 2 in ethanol. 3a–l were tested for their abilities to inhibit lipid peroxidation (LP), scavenge DPPH• and ABTS•+ radicals, and to reduce Fe3+ to Fe2+. Most of the tested compounds exhibited potent scavenging activities against ABTS•+ radical, reducing powers and strong inhibitory capacity on LP. 3 a, 3 d, 3e, 3h, 3j and 3 k chosen as prototypes were evaluated in the National Cancer Institute’s in vitro primary anticancer assay. The greatest growth inhibitions were observed against a non-small cell lung cancer cell line HOP-92 for R1-fluoro substituted 3 d and a renal cancer cell line RXF-393 for R-chloro substituted 3 e in the primary screen.