A. Militaru, Adriana Smarandache, A. Mahamoud
Aug 29, 2011
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Abstract
3‐[2‐(dimethylamino)ethyl]‐6‐nitroquinazolin‐4(3H)‐one, labeled BG1188, is a new synthesized compound, out of a series of quinazoline derivatives developed to fight the multidrug resistance of antibiotics acquired by bacteria. A characterization of the BG1188 powder was made using FTIR spectra in order to evidence the functional groups in the medicine’s molecule. The ultraviolet‐visible (UV‐Vis) absorption spectra were used to study the stability of the BG1188 solutions in two solvents and at different temperatures. BG1188 concentration in ultrapure water was varied between 2×10−3 M (stock solution) and 10−6 M. The concentration recommended by higher activity on bacteria was 10−3 M. For the same reason, this was the utilized concentration of BG1188 in dimethyl sulfoxide (DMSO). Time stability was characterized by comparing the time evolution of the UV‐Vis absorption spectra of the BG1188 solutions in ultrapure de‐ionized water or in DMSO. The spectra were recorded daily for about 4 months after the prepar...