D. Alexander, S. Böhm, I. Císařová
2000
Citations
0
Influential Citations
3
Citations
Journal
Collection of Czechoslovak Chemical Communications
Abstract
A selective hexa-fold monoalkylation of the malonester carbanion (-) CH(COOR) 2 (R = Me, Et, t -Bu, Bn) with hexakis(bromomethyl)benzene afforded the title compounds 3 in a high-yield reactions. On subsequent replacement of the acid α-hydrogens with bulkier substituents, the title compounds 3 , R = Et, provided a broad variety of the α-X-persubstituted homologues and derivatives 4 (X = Me, Et, Bu, Oc, Bn, Br, N 3 ). The effect of the variable X substituent on conformation was investigated by single-crystal X-ray diffraction and compared with the results obtained by theoretical calculation.