Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives

doi:10.1016/S0166-2236(99)01399-5

Paper

DOI: 10.1016/S0166-2236(99)01399-5

Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives

Published Sep 1, 1999 · R. Rupprecht, F. Holsboer

Trends in Neurosciences

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652

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Abstract

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Study Snapshot

Neuroactive steroids influence neuronal function, sleep, and memory, and may play a role in stress response and psychiatric disorders like depression.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1007/s002130050916

Assessment of neuroleptic-like properties of progesterone

Progesterone has neuroleptic-like properties, potentially contributing to the development and treatment of psychotic disturbances by sharing properties with atypical antipsychotics.

1999·67citations·R. Rupprecht et al.·Psychopharmacology

Psychopharmacology

DOI: 10.1016/S0306-4530(98)00071-7

NEUROSTEROIDS: A NOVEL FUNCTION OF THE BRAIN

Neurosteroids play a physiological role in the central and peripheral nervous systems, with potential applications in memory and nerve repair.

1998·604citations·E. Baulieu·Psychoneuroendocrinology

Psychoneuroendocrinology

DOI: 10.1210/MEND.12.9.0163

Functional antagonism of gonadal steroids at the 5-hydroxytryptamine type 3 receptor.

Gonadal steroids, such as 17beta-estradiol and progesterone, may act as functional antagonists at the 5-HT3 receptor, potentially impacting nausea during pregnancy and psychiatric disorders.

1998·134citations·C. Wetzel et al.·Molecular endocrinology

Molecular endocrinology

DOI: 10.1176/AJP.155.7.910

Effects of antidepressant treatment on neuroactive steroids in major depression.

Successful antidepressant therapy may correct imbalances in neuroactive steroids, potentially benefiting patients with major depression.

1998·457citations·E. Romeo et al.·The American journal of psychiatry

The American journal of psychiatry

DOI: 10.1016/S0166-2236(97)01209-5

The effects of steroid hormones on electrical activity of excitable cells

Steroid hormones influence electrical activity of neurons and effectors by regulating ion channel and neurotransmitter receptor transcription, modulating channel and receptor activity, or both.

1998·113citations·H. Zakon·Trends in Neurosciences

Trends in Neurosciences

Citations

DOI: 10.1016/j.bmc.2024.118006

Use of imidazo[1,5-a]quinoline scaffold as the pharmacophore in the design of bivalent ligands of central benzodiazepine receptors.

The imidazo[1,5-a]quinoline scaffold effectively designed bivalent central benzodiazepine receptor ligands with anticonvulsant and anxiolytic properties without muscle relaxant effects or learning and memory impairments.

2024·0citations·M. Paolino et al.·Bioorganic & medicinal chemistry

Bioorganic & medicinal chemistry

DOI: 10.32641/andespediatr.v95i5.5229

[Polycystic Ovary Syndrome and Mental Health in Adolescents].

Women with PCOS are at increased risk of mental health disorders and neurodevelopmental disorders, highlighting the need for active assessment and coordination of care.

2024·0citations·María Rosario Matte et al.·Andes pediatrica : revista Chilena de pediatria

Andes pediatrica : revista Chilena de pediatria

DOI: 10.1016/j.bcp.2024.116481

The emergence of antidepressant drugs targeting GABAA receptors: A concise review.

New antidepressants targeting GABAA receptors show promise for improving efficacy and faster onset of action in treating depression, with potential benefits for various subtypes.

2024·3citations·Xenia Gonda et al.·Biochemical pharmacology

Biochemical pharmacology

DOI: 10.1016/j.jsbmb.2024.106464

5β-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia

Compound 42, a 5-reduced neuroactive steroid, significantly promotes postnatal neuron survival and growth, with glial function being critical for neuron growth support.

2024·0citations·Marie Munawar Cheema et al.·The Journal of Steroid Biochemistry and Molecular Biology

The Journal of Steroid Biochemistry and Molecular Biology

DOI: 10.3390/app13158880

Photobiomodulation as a Therapeutic Strategy in Burning Mouth Syndrome: A Scoping Review

Photobiomodulation therapy shows promising results in reducing symptoms of burning mouth syndrome, offering a potential therapeutic alternative.

2023·1citation·F. Spadari et al.·Applied Sciences

Applied Sciences

DOI: 10.1016/j.neubiorev.2023.105327

Neurosteroid influence on affective tone

Neurosteroids influence affective states, with exogenous neurosteroids playing a significant role in depression and anxiety, and endogenous neurosteroids potentially setting a baseline affective tone.

2023·5citations·N. Walton et al.·Neuroscience & Biobehavioral Reviews

Neuroscience & Biobehavioral Reviews

DOI: 10.3390/ijms24109056

Neurosteroids Mediate Neuroprotection in an In Vitro Model of Hypoxic/Hypoglycaemic Excitotoxicity via δ-GABAA Receptors without Affecting Synaptic Plasticity

Neurosteroids, such as XBD173, show promising potential for post-ischaemic recovery by providing neuroprotection without detrimental effects on synaptic plasticity.

2023·1citation·Xènia Puig-Bosch et al.·International Journal of Molecular Sciences

International Journal of Molecular Sciences