G. Qu, Zhi-Jie Mao, H. Niu
Mar 18, 2009
Citations
0
Influential Citations
33
Citations
Journal
Organic letters
Abstract
A novel approach to the synthesis of purines bearing functionalized carbon substituents or methyl in position 6 was developed. Under different reaction conditions, 6-halopurine derivatives could react with ethyl acetoacetate efficiently to yield 2-(purin-6-yl)acetoacetic acid ethyl esters, (purin-6-yl)acetates and 6-methylpurines respectively. No metal catalyst and ligand were required.