Synthetic strategies, SAR studies, and computer modeling of indole 2 and 3-carboxamides as the strong enzyme inhibitors: a review

doi:10.1007/s11030-020-10061-x

Paper

Synthetic strategies, SAR studies, and computer modeling of indole 2 and 3-carboxamides as the strong enzyme inhibitors: a review

Published May 12, 2020 · G. Chehardoli, Asrin Bahmani

Molecular Diversity

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14

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Abstract

Abstract Indole derivatives have been the focus of many researchers in the study of pharmaceutical compounds for many years. Researchers have investigated the effect of carboxamide moiety at positions 2 and 3, giving unique inhibitory properties to these compounds. The presence of carboxamide moiety in indole derivatives causes hydrogen bonds with a variety of enzymes and proteins, which in many cases, inhibits their activity. In this review, synthetic strategies of indole 2 and 3-carboxamide derivatives, the type, and mode of interaction of these derivatives against HLGP, HIV-1, renin enzyme, and structure–activity studies of these compounds were investigated. It is hoped that indole scaffolds will be tested in the future for maximum activity in pharmacological compounds. Graphic abstract

Literature Review

Study Snapshot

Indole 2 and 3-carboxamide derivatives show potential as strong enzyme inhibitors, with potential for future pharmaceutical compounds.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthetic strategies, SAR studies, and computer modeling of indole 2 and 3-carboxamides as the strong enzyme inhibitors: a review

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References

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The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in cardiovascular and renal diseases, and suppressing it can potentially improve quality of life and survival.

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Indolchromins A and B, synthesized from indole-3-carbinol by Daldinia eschscholzii, show potential as cytotoxic and antibacterial agents against various bacteria and human breast cancer cell lines.

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Indole-based small molecules show potential as antibacterial agents, offering promising leads in antibiotic drug discovery research.

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