Why Stress Is Bad for Your Brain

doi:10.1126/science.273.5276.749

Paper

DOI: 10.1126/science.273.5276.749

Why Stress Is Bad for Your Brain

Published Aug 9, 1996 · R. Sapolsky

Science

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1,333

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Abstract

Several recent studies of humans correlate stress with atrophy of the hippocampus, an area of the brain required for memory and cognition. In his Perspective, Sapolsky argues that the underlying causal agent may be glucocorticoids secreted in abnormally high amounts under stressful conditions.

Highly Cited

Study Snapshot

Stress can lead to atrophy of the hippocampus, a brain area crucial for memory and cognition, with glucocorticoids playing a role in this process.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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