THE STRUCTURAL MODIFICATION CAUSES THE ENHANCEMENT OF ANALGESIC ACTIVITY OF 4-(4' CHLORO -PHENYL)-4- HYDROXY PIPERIDINE

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THE STRUCTURAL MODIFICATION CAUSES THE ENHANCEMENT OF ANALGESIC ACTIVITY OF 4-(4' CHLORO -PHENYL)-4- HYDROXY PIPERIDINE

Published Feb 1, 2014 · Kiran Rafiq, Z. S. Saify, R. Kausar

Asian Journal of Pharmaceutical and Clinical Research

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Abstract

Objective- The outstanding position of piperidine analogues has proven them an important core in the structures of pharmaceutically active molecules, naturally occurring alkaloids, pharmaceuticals and as synthetic intermediates with interesting biological, physical and pharmacological behaviors. The piperidine ring containing compound like pethidine having strong opiod analgesic activity, more potent than codein and controls the pain of smooth muscle spasm. Because of having similarity in structure the present study was aimed to estimate the analgesic activity of synthesized derivatives of 4-(4′-Chlorophenyl)-4-hydroxy piperidine. Method- The present study was conducted in animal model, mice by using Pethidine as standard drug. For which the Eddy’s hot plate method was adopted and analgesia ( mean increase in latency) was observed. Result- The result showed the more prominent response of substituted compound than the parent one “4-(4′-Chlorophenyl)-4-hydroxy piperidine” and it was studied that alteration in the molecule structure is accountable for a better analgesic response. Conclusion- The studies proved the positive pharmacological responsiveness of the combination of 4-(4′-Chlorophenyl)-4-hydroxy piperidine with phencyl halides. These synthesized derivatives will establish as potent analgesics.

Non-RCT

Animal Study

Study Snapshot

The structural modification of 4-(4′-Chlorophenyl)-4-hydroxy piperidine with phencyl halides enhances its analgesic activity, making it a promising potent analgesic.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

THE STRUCTURAL MODIFICATION CAUSES THE ENHANCEMENT OF ANALGESIC ACTIVITY OF 4-(4' CHLORO -PHENYL)-4- HYDROXY PIPERIDINE

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References

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Citations

Synthesis, Pharmacological Evaluation and In-Silico Studies of Some Piperidine Derivatives as Potent Analgesic Agents

PP1, AMP5, and AMP6 show potent analgesic activity, with potential interaction with mu-opioid receptors and good binding affinity.