Ashwini Gumireddy, Kevin DeBoyace, Alexander Rupprecht
Mar 5, 2021
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Journal
Acta Crystallographica Section E: Crystallographic Communications
Abstract
A sterically congested piperazine derivative, tert-butyl 4-[4-(4-fluorophenyl)-2-methylbut-3-yn-2-yl]piperazine-1-carboxylate, was prepared using a modified Bruylants approach. Its novel chemistry with a synthetically useful second nitrogen atom on the N-tert-butyl piperazine substructure generates a pharmacologically useful core.