S. Marwaha, M. H. Rubinstein
May 1, 1988
Citations
1
Influential Citations
27
Citations
Journal
International Journal of Pharmaceutics
Abstract
Abstract Six batches of magnesium stearate containing 0%:100%, 10%:90%, 15%:85%, 25%:75%, 30%:70% and 100%:0% magnesium stearate : magnesium palmitate have been synthesised. The specific surface area and differential thermal analysis of each lubricant was measured together with X-ray diffraction studies on the 15%:85% sample. 1% w/w of each lubricant was mixed with lactose and the mixture was compressed at various compaction pressures and speeds. It was found that there was no correlation between the surface area of the lubricants, their chemical composition and lubricant efficiency. The X-ray crystallographic data indicated that the unit cell was a primitive tricyclic subcell of the P′2 arrangement. An evaluation of the compaction characteristics of the lubricants indicated that minimal energy is required to compress satisfactorily the 25%:75% sample and this lubricant also required the least amount of energy to eject tablets from the die. It was concluded that the lubricant was a 25%:75% ratio of magnesium stearate to palmitate, which was found to be far superior to the technical grade of magnesium stearate also investigated.