J. D. Conklin, R. D. Hollifield
Jun 1, 1970
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
European journal of pharmacology
Abstract
Abstract A sensitive and specific spectrophotofluorometric procedure is described for the determination of amiquinsin hydrochloride, a hypotensive drug, in biologic materials. Results are presented which show that either oral or parenteral dosage of amiquinsin HCl to dogs yields blood drug levels which are dose related and linear urinary drug dose responses. At least 1 5 of the dose usually is recovered in urine under these conditions. Intravenous administration of amiquinsin HCl to dogs results in a biphasic drug disappearance curve in blood. Only low concentrations of amiquinsin HCl were detectable in the bile, aqueous humor, and cerebrospinal fluid of the dog. Although no major specific tissue binding sites were apparent for amiquinsin HCl in the dog, the drug was found in most tissues at levels greater than those currently present in blood. Evidence is also presented which indicates that there is placental transfer of amiquinsin HCl in the guinea pig, rabbit, dog, and sheep.