Vrushali T. Kale, Subodh A.Bhandarkar, A. S. Burghate
Feb 1, 2020
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Journal
Journal of emerging technologies and innovative research
Abstract
In the present study, we have reported the synthesis, spectral studies and biological evolution of substituted hydrazone schiff’s bases derivatives of benzothiazolyl and benzimidazolyl for antifungal activity. In the present research series of 2-[1-(Benzothiazole-2-yl hydrazono)-ethyl]-5-methyl phenol, 2-(Benzothiazole-2-yl hydrazono)-methyl)phenol, N-Benzothiazole-2-yl-N-(1-4-chloro-phenyl)ethylidene]-hydrazine ,2-[1-H-Benzimidazole-2-yl hydrazono)-methyl]-4-methyl phenol were synthesized by green chemistry technique. Structures of all the newly synthesized compounds were confirmed by their IR, H-NMR and CHN analysis. The antifungal activities of these synthesized compounds are done by cup plate method The fresh cultures of Candida albicans (NCIM 3103). Present work was based on the synthesis of substituted benzothiazole derivatives in order to find out the antifungal activity against C. albicans and Pityrosporium ovalue. since Candida albicans is mainly responsible for skin infection, especially in the epithelial cells of the vagina. Candida albicans is a yeast that commensally inhabits the human body and can cause opportunistic or pathogenic infections.