Pharmacological Studies on the Anti-inflammatory Action of Phenolic Compounds

doi:10.1177/00220345860650010901

Paper

Pharmacological Studies on the Anti-inflammatory Action of Phenolic Compounds

Published Jan 1, 1986 · Y. Azuma, N. Ozasa, Y. Ueda

Journal of Dental Research

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89

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Abstract

The mechanism of the anti-inflammatory action of phenolic compounds was examined using neutrophil chemotaxis. Chemotactic activity of guinea pig peritoneal neutrophils to N-formylmethionyl-leucylphenylalanine (FMLP) was suppressed in a concentration-dependent manner. The order of drug potency in inhibiting the neutrophil chemotaxis was eugenol » thymol > guaiacol » phenol. The concentrations of phenolic compounds used in these experiments did not induce lactate dehydrogenase (LDH) release and did not affect neutrophil viability. There was a consistent positive relation between the ID50 of superoxide anion generation in neutrophils and the inhibitory dose for neutrophil chemotaxis by phenolic compounds. A free phenolic hydroxyl group is essential for scavenging oxygen free-radicals and is also essential for inhibiting leukocyte chemotaxis, as was demonstrated in these experiments. These findings suggest that inhibition of leukocyte chemotaxis may be involved in the anti-inflammatory action of phenolic compounds, and that one of the anti-inflammatory actions of phenolic compounds is the prevention of the production of oxygen free-radicals by leukocytes.

In Vitro Study

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Study Snapshot

Phenolic compounds inhibit leukocyte chemotaxis and prevent oxygen free-radical production by leukocytes, potentially contributing to their anti-inflammatory properties.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Pharmacological Studies on the Anti-inflammatory Action of Phenolic Compounds

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References

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Phenolic compounds with two aromatic rings connected by a short bridge can effectively inhibit prostaglandin cyclooxygenase, with 2-benzyloxyphenol and 2,4,6-trimethylphenol being more potent than indomethacin in platelet aggregation inhibition.

A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration.

The 48-well micro chemotaxis chamber provides rapid and accurate measurements of leukocyte migration, suitable for clinical research on monocyte function in large groups of patients.

Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.

Superoxide dismutase effectively suppresses inflammation by inhibiting the production of a neutrophil chemotactic factor, which plays a key role in communication in neutrophil-mediated inflammatory events.

Inhibition of the neutrophil oxidative response to a chemotactic peptide by inhibitors of arachidonic acid oxygenation.

Inhibitors of arachidonic acid oxygenation can inhibit neutrophil oxidative metabolism and enzyme release stimulated by a chemotactic peptide.

Chlorpromazine inhibits phagocytosis and exocytosis in rabbit polymorphonuclear leukocytes.

Chlorpromazine inhibits both phagocytosis and exocytosis in rabbit polymorphonuclear leukocytes, affecting enzyme release independently of its effect on phagocytosis.

Citations

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