A. C. Barrios Sosa, D. Boschelli, Biqi Wu
Mar 15, 2005
Citations
0
Influential Citations
15
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
Several new ethynyl- and ethenyl-4-phenylamino-3-quinolinecarbonitriles were synthesized and tested for Src inhibition. Derivatives bearing an ethenyl or ethynyl substituent at C-6 showed decreased Src inhibitory activity. Incorporation of an ethenylpyridine N-oxide group at C-7 provided 20b, a 0.6 nM inhibitor of Src enzymatic activity with excellent cellular potency.