Y. Sharma, H. C. Malhotra, G. C. Sharma
2018
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Journal
Asian Journal of Chemistry
Abstract
d-2,2-(Ethylenediimino)-di-1-butanol (ethambutol) is a synthetic compound and is used in the treatment of tuberculosis [1]. Its antibacterial spectrum is limited to mycobacteria and only growing cells are affected by inhibiting mycobacterial RNA synthesis. Like EDTA, it is a good chelating agent [2,3]. So it is of interest to examine the effect of d-2,2-(ethylenediimino)-di-1-butanol on our plasma model. To understand these vital processes and steps of metal binding to the ligand, it was thought desirable to carry out a comprehensive kinetic study on the interaction of Ni(II) with d-2,2-(ethylenediimino)-di1-butanol. Therefore, the kinetics of complexation of metal ions Ni(II) by d-2,2-(ethylenediimino)-di-1-butanol would no doubt give important information regarding the types of interaction of these ions with d-2,2-(ethylenediimino)-di-1-butanol and the clearance of d-2,2-(ethylenediimino)-di-1-butanol in the form of metal-ligand complex through the animal body [4-7]. With the hope that these anomalies might have rational explanation and to understand the biological processes clearly, a comprehensive kinetic study has been undertaken on the reaction of Ni(II) with d-2,2-(ethylenediimino)-di-1-butanol.